Vitamin D Upregulates Neurotrophins


Neurotrophins are the family of proteins that induce the development, function, and survival of nerve and brain cells.

Vitamin D upregulates neurotrophins, such as NGF (nerve growth factor) and GDNF (glial-derived neurotropic factor), up to fivefold.


Neveu I, Naveilhan P, Jehan F, Baudet C, Wion D, De Luca HF, Brachet P. 1,25-dihydroxyvitamin D3 regulates the synthesis of nerve growth factor in primary cultures of glial cells. Brain Res Mol Brain Res. 1994 Jul;24(1-4):70-6.

Orme RP, Bhangal MS, Fricker RA. Calcitriol imparts neuroprotection in vitro to midbrain dopaminergic neurons by upregulating GDNF expression. PLoS One. 2013 Apr 23;8(4):e62040.

Holtzman DM, Mobley WC. Neurotrophic factors and neurologic disease. West J Med. 1994 Sep;161(3):246-54.

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