Turn Off Your Body’s Aging “Switch”


“In an important scientific advance, researchers have uncovered a biochemical “switch” that turns on many of the chronic diseases of aging.

The name of this newly identified “switch” is HMGB1, which stands for “High Mobility Group Box-1”.

HMGB1 turns on the release of chemical signals called cytokines that generate inflammation in your body.

The more chronic inflammation you have, the more rapidly your body ages. The tragic consequence of higher levels of inflammation is the acceleration of chronic diseases that cause premature death and disability.

Once scientists uncovered the switch that “turns on” chronic inflammation, they began looking for a safe and effective means of “turning off” that switch.

Researchers have found two natural ingredients that can directly control HMGB1, thus reducing the body’s exposure to chronic inflammation, and ultimately protecting against inflammation-induced disorders.”

Excerpt from article “Turn Off Your Body’s Aging “Switch””, by Morris Eagleton, Life Extension Magazine Winter Edition 2013-2014


Nogueira-Machado JA, de Oliveira Volpe CM. HMGB-1 as a target for inflammation controlling. Recent Pat Endocr Metab Immune Drug Discov. 2012 Sep;6(3):201-9.

Strzelecka M, Bzowska M, Kozieł J, et al. Anti-inflammatory effects of extracts from some traditional Mediterranean diet plants. J Physiol Pharmacol. 2005 Mar;56 Suppl 1:139-56.

Li W, Ashok M, Li J, Yang H, Sama AE, Wang H. A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1. PLoS One. 2007;2(11):e1153.

Zhu S, Li W, Li J, Jundoria A, Sama AE, Wang H. It is not just folklore: The aqueous extract of mung bean coat is protective against sepsis. Evid Based Complement Alternat Med. 2012;2012:498467.

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