Methylation relies on B-vitamin cofactors:
- Vitamin B6
- Vitamin B12
for the proper synthesis of the neurotransmitters that play an important role in mood regulation.
The methylation cycle becomes impaired, due to an decline in the B-vitamin cofactors which then leads to a concurrent increase in homocysteine levels. The end result is a disruption in neurotransmitter synthesis.
There is a close relationship between neurotransmitter synthesis and homocysteine formation, and that levels of homocysteine are an effective marker for B-vitamin status, and that changes in homocysteine levels correlate with changes in mood.
A target blood level of less than 7 – 8 µmol/L of homocysteine helps to ensure proper neurotransmitter metabolism and may balance mood during times of stress, depression and anxiety.
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