Terminalia chebula: Effective Glycation Inhibitor


Terminalia chebula is a medium to large deciduous tree growing to 30-metre (98 ft) tall, is a species of Terminalia, native to South Asia from India and Nepal east to Southwest China (Yunnan), and south to Sri Lanka, Malaysia and Vietnam.

In Ayuryedic medicine, Terminalia checula is known as Haritaki and is one of three herbs in a combination formula called Triphala, which means “three fruits” in Hindi/Sanskirt. The three fruits in Triphala are Amalaki (Emblica officinalis), Bibhitaki (Terminalia bellirica), and Haritaki (Terminalia chebula).

Chebulic acid is a phenolic compound isolated from the ripe fruits of Terminalia chebula. Chebulic acid has been studied for its ability to neutralizes free radicals and reduce AGE formation.

The research on Terminalia chebula and chebulic acid indicates that it is seven times more effective at reducing glycation than the well-known glycation inhibitor aminoguanidine.

Chebulic acid demonstates the ability to break the bond existing between abnormally cross-linked proteins.


Lee HS, Koo YC, Suh HJ, Kim KY, Lee KW. Preventive effects of chebulic acid isolated from Terminalia chebula on advanced glycation endproduct-induced endothelial cell dysfunction. J Ethnopharmacol. 2010;131(3):567-74.

Lee HS, Cho HY, Park KW, et al. Inhibitory effects of Terminalia chebula extract on glycation and endothelial cell adhesion. Planta Med. 2011 Jul;77(10):1060-7.

Lee JY, Oh JG, Kim JS, Lee KW. Effects of chebulic acid on advanced glycation end products-induced collagen cross-links. Biol Pharm Bull. 2014 Apr 24.



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