Sirtuins are a group of endogenous histone COAs enzymes produced by the S IR 2G. There are seven known human Sirtuins:

  • Sirtuin 1 (SIRT1)
  • Sirtuin 2 (SIRT2)
  • Sirtuin 3 (SIRT3)
  • Sirtuin 4 (SIRT4)
  • Sirtuin 5 (SIRT5)
  • Sirtuin 6 (SIRT6)
  • Sirtuin 7 (SIRT7)

The following substances have been known to enhance the function of Sirtuins:

Nicotinamide Adenine Dinucleotides (NAD)
NAD is an essential cofactor for the activation of Sirtuins. [1]

Melatonin may increase the activity of some types of Sirtuins, particularly SIRT. [2]

Resveratrol may increase the activity at S IR, and may be a possible SIRT1 activator. [3]


[1] Guarente, L. Sir2 links chromatin silencing, metabolism and aging. Genes Dev. 14(9):1021-1026, 2000
[2] Chang, H. M., et al. Melatonin preserves longevity protein (sirtuin 1) expression in the hippocampus of total sleep-deprived rats. J Pineal Res. 47(3):211-220, 2009
[3] Borra, M. T., et al. Mechanism of human SIRT1 activation by resveratrol. J Biol Chem. 2005; Howitz, K. T., et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003.

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