Prevention and Early Intervention of Cancer by Reducing Serum Levels of the ENOX2 (tNOX) Protein With Green Tea and Capsicum annuum

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ENOX is a gene that encodes the protein Ecto-NOX disulfide-thiol exchanger, a member of the NOX family of NADPH oxidases.   Research has discovered three known classes of ENOX proteins:

  • ENOX1 is found normally in most cells
  • ENOX2 is found in cancers
  • ENOX3, also known as arNOX, is an age-related class of proteins

These three ENOX proteins are involved in:

  • aging
  • biological time keeping
  • cancer
  • cell growth
  • viral infections

ENOX2 Protein As Indicator of Cancerous Cells

Ecto-Nicotinamide Adenine Dinucleotide Oxidase Disulfide-Thiol Exchanger 2 (ENOX2), also known as Tumor-Associated Nicotinamide Adenine Dinucleotide Oxidase (tNOX), is specific for cancer by coating the surfaces of malignant cells and disrupting apoptosis signals to execute programmed cell death of the malignant cell.  ENOX2 allows immature cancer cells to enlarge to a normal size.  Essentially, cancers cells cannot survive or grow without ENOX2.

ENOX2 is produced only by cancer cells and not healthy normal cells. 

A distinct function of ENOX2 is the oxidation of NADH to NAD+ in an oscillating fashion.  This process is accomplished within a period of 24 minutes, completing 60 cycles in a 24 hour period.  This 60 cycles of 24 minutes is considered a regular oscillation of the biological clock.  The period of oscillation in a cancerous cell is reduced to 22 minutes.  1

Detection of ENOX2 in the Serum with the ONCOblot® Test

The presence of ENOX2 in the blood serum is a marker for the presence of cancer and represents a non-invasive approach to cancer detection.  ENOX2 has become a target for early diagnosis of cancer as well as for early preventive intervention. 

The researchers D. James Morré, PhD and Dorothy Morré, PhD created the ONCOblot® Test which identifies ENOX2 in the blood.   Since ENOX2 proteins are shed into the circulation, they can be detected in the blood through this test.

The ONCOblot® Test has been shown to detect ENOX2 as early as Stage 0. The limit of detection is an estimated 2 million cells (2 mm or less tumor mass, roughly the size of a pinhead).   The ONCOblot® Test can reputedly differentiate among 26 different types of cancer.

Inhibiting ENOX2 With Natural Substances

A research paper published in 2014 in Clinical Proteomics studied the effects of a natural substance formula on patients testing positive using the ONCOblot® Test.  2

The study used 110 patients that tested positive for cancer presence using the ONCOblot® Tissue of Origin 2-D gel/western blot protocol for detection of serum presence of transcript variants of the ENOX2 protein.

Those patients that tested positive for ENOX2 were given a 350 mg capsule of Capsol-T® every 4 hours including during the night for periods of at least 3 to 6 months or longer.  Patients consumed a total of 6 capsules per 24 hour period for a total of 2,100 mg.

Capsol-T® is a mixture of decaffeinated green tea (Camellia sinensis) plus Capsicum (Capsicum annuum) powder in the form of 350 mg gel capsules.  The capsules contained the two ingredients in a ratio of 25:1 (green tea:capsicum). The caffeine content of the 350 mg Capsol-T® product was 0.472% (1.65 mg caffeine). 

The breakdown using this 25:1 ratio is as follows:

Per Capsule

336 mg green tea          96%

14 mg capsicum              4%

350 mg total capsule     100%

Total of 6 Capsules

2,016 mg  green tea       96%

84 mg capsicum               4%

2,100 mg total              100%

The synergistic combination of decaffeinated green tea and capsicum resulted in a 100 fold increase in killing of cultured cancer cell lines compared to green tea alone.  3  Cancer cells with blocked ENOX2 activity are not able to enlarge and are thus directed towards apoptosis (programmed cell death).

After completion of 3 to 17 months of Capsol-T® use, 94% of subjects subsequently tested negative for ENOX2 presence.   Oral Capsol-T® is consistently effective in reducing the serum ENOX2 levels to below detectable limits.  4

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