Polypodium leucotomos may reduce the overproduction of Interleukin 6 (IL-6) by up to 100%


Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine.   1   The function of IL-6 is beyond the scope of this article.  Instead, the focus here is the excessive production of IL-6 and its implication in a variety of inflammatory disorders.   2

IL-6 stimulates the inflammatory and auto-immune processes in many diseases such as

  • Alzheimer’s Disease  3
  • Atherosclerosis  4
  • Behçet’s disease  5
  • Depression  6
  • Diabetes  7
  • Multiple myeloma  8
  • Prostate cancer  9
  • Rheumatoid arthritis  10
  • Systemic lupus erythematosus  11

A study published in the May-June 2000 edition of the Journal Anticancer Research, entitled, An extract of the fern Polypodium leucotomos (Difur) modulates Th1/Th2 cytokines balance in vitro and appears to exhibit anti-angiogenic activities in vivo: pathogenic relationships and therapeutic implications, showed that an extract of the fern Polypodium leucotomos (PLE) to partially inhibit the production of cytokines showing a Th1 pattern (IL-2, IFN-gamma and TNF-alpha) in human PHA-stimulated peripheral blood mononuclear cells.  12

The authors were surprised to find:

“that the production of the inflammatory cytokine IL-6 was completely abolished (100% inhibition) by PLE at all doses tested.”  13

Polypodium leucotomos is also known as and is an epiphytic fern native to tropical and subtropical regions of the Americas.  An extract of Polypodium leucotomos called Fernblock has proven photoimmunoprotection  properties with oral and topical application.

The extract has extensive preclinical and clinical data supporting its safety and efficacy in protecting against damage caused by solar radiation, and preventing and treating sun-related disorder.  14  15

Informational References:

Industrial Farmaceutica Cantabria. S.A. – Fernblock®


Polypodium Leucotomos Extract 240mg ~ 200 Capsules – No Additives ~ Naturetition Supplements

Polypodium Leucotomos Extract 240mg * 200 Capsules 100 % Natural – by EarhNaturalSupplements

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