Oroxylin A facilitates memory consolidation through an increase in BDNF

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Oroxylin A is a chemical compound known as a flavone that is primarily found in the medicinal plant Scutellaria baicalensis.  1

Scutellaria baicalensis, or Baikal skullcap or Chinese Skullcap, (Huang Qin or 黄芩, 黃芩) is a plant cultivated in Siberia, Mongolia, the Russian Far East, China and Korea. 

BaicalSkullcap

Scutellaria baicalensis roots

In a study published in September 2014 in the Brain Research Bulletin, the data from the researchers suggest that Oroxylin A facilitates memory consolidation through BDNF-TrkB signaling and confirms that the increase of BDNF in a specific time window plays a crucial role in memory consolidation.  2

The study investigated the role of Oroxylin A on the memory consolidation process in mice. Oroxylin A improved the memory retention administered at 0 h, 1 h and 3 h after training in a passive avoidance task, suggesting that Oroxylin A facilitates memory consolidation.

Oroxylin A increased mature brain-derived neurotrophic factor (mBDNF) levels in the hippocampus from 6h to 24h after administration. Moreover, 3h post-training administration of Oroxylin A enhanced the mBDNF level at 9h after the acquisition trial compared to the level at 6h after the acquisition trial. However, 6h post-training administration of Oroxylin A did not increase the mBDNF level at 9h after the acquisition trial.


Resources:

Biofoundations.net – Huang Qin – Chinese Skullcap (Root)


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