Nutrients that Support Phase I and Phase II Detoxification Metabolism


Phase I, II, and III metabolisms have different biochemical requirements and respond to different metabolic signals, but must work in unison for proper removal of unwanted xenobiotics (such as toxins or drugs) or endobiotics (such as excess hormones).

The Phase I and II detoxification processes need to be supported by various nutrients in order to properly function.

Below is a list of the more important nutrients required for proper phase I and II functions:

Phase I Detoxification

  • Activation/Oxidation
    • Vitamin C
    • Vitamin E
    • Bioflavonoids
    • B Complex Vitamins
    • Glutathione
    • Branched Chain Amino Acids

Phase II Detoxification

  • Sulfation
    • Sulfur in the form of:
      • Methionine
      • Cysteine
      • Taurine
      • Alpha Lipoic Acid
      • Glutathione
      • N-Acetyl-Cysteine
      • MSM (methylsulfonylmethane)
    • Methylation
      • Choline
      • SAMe (s-adenosylmethionine)
      • DMG (dimethylglycine)
      • TMG (trimethylglycine)
      • DMAE (dimethylaminoethanol)
    • Glucuronidation
      • Glucuronic Acid
      • Calcium D-Glucarate
    • Glycination (hippration)
      • Glycine
    • Mercapturation
      • Glutathione
      • N-Acetyl-Cysteine
    • Acetylation
      • Coenzyme A
      • Pantethine

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