Nutrients that Enhance the Function of Nitric Oxide


Nitric Oxide (NO) is an important cellular signaling molecule that acts as a powerful vasodilator. NO signals the surrounding smooth muscles of the arteries to relax and dilate, which increases healthy blood flow throughout the body.

The following nutrients have been studied and researched for their ability to enhance the function of nitric oxide:


Jablecka, A., et al. The influence of two different doses of L-arginine oral supplementation on nitric oxide (NO) concentration and total antioxidant status (TAS) in atherosclerotic patients. Med Sci Monit. 10(1):29-32, 2004

Chowienczyk, P., et al. Arginine: NO more than a simple amino acid? Lancet. 350(9082):901-902, 1997

Benelli, A., et al. Nitric oxide is involved in male sexual behavior of rats. Eur J Pharmacol. 249(2-3):505-510, 1995


Raghavan, S. A., et al. L-citrulline mediated relaxation in the control and lipopolysaccharide-treated rat aortic rings. Eur J Pharmacol. 431(1):61-69, 2001


Hiou, C. S., et al. Effects of hesperidin on cyclic strain-induced endothelin-1 release in human umbilical vein endothelial cells. Clin Exp Pharmacol Physiol. 2008


Akahashi, S., et al. Carnosine facilitates nitric oxide production in endothelial f-2 cells. Biol Pharm Bull. 32(11):1836-1839, 2009


Fitzpatrick, D. F., et al. Endothelium-dependent vascular effects of Pycnogenol. J Cardiovasc Pharmacol. 32(4):509-515, 1998


Gresele, P., et al. Resveratrol, at concentrations attainable with moderate wine consumption, stimulates human platelet nitric oxide production. Journal of Nutrition. 138(9):1602-1608, 2008

Vitamin C

Taddei, S., et al. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation. 97(22):2222-2229, 1998

Vitamin E

Khosh, F. Natural approach to hypertension. Alternative Medicine Review. 6(6), 2001


Keen, C. L., et al. Cocoa antioxidants and cardiovascular health. American Journal of Clinical Nutrition. 81(1 Supplement):298S-303S, 2005


Bhattacharyya, M., et al. Systemic production of IFN-alpha by Garlic (Allium sativum) in humans. J Interferon Cytokine Res. 27(5):377-382, 2007


Ignarro, L. J., et al. Pomegranate juice protects nitric oxide against oxidative destruction and enhances the biological actions of nitric oxide. Nitric Oxide. 2006


Tanner, M. A., et al. The direct release of nitric oxide by gypenosides derived from the herb Gynostemma pentaphyllum. Nitric Oxide: Biology and Chemistry. 3(5):359-365, 1999 


Chen, J., et al. Effect of the plant-extract osthole on the relaxation of rabbit corpus cavernosum tissue in vitro. Journal of Urology. 163(6):1975-1980, 2000

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