Nuclear Factor-Kappa B (NF-Kappa B or NF-κB): Effects and Natural Substances that May Inhibit Elevated Levels

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NF-κB plays a key role in regulating the immune response to infection (κ light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory, and autoimmune diseases, septic shock, viral infection, and improper immune development.

Table:  Effects of Nuclear Factor-Kappa B

NF-Kappa B

 

 

Cause

Effect

Reference(s)

Depression

 

 

 

Excessive activation of NF-Kappa B may contribute to Depression.

  [1]

Synaptic plasticity

 

 

 

NF-κB may regulate learning and memory in part by modulating synaptic plasticity

  [2]

Synapse function

 

 

 

Excessive NF-κB may disrupt synaptic function

  [3]

Memory Impairment

 

 

 

NF-Kappa B may contribute to Memory impairment.

  [4]

Migraines

 

 

 

Excessive activation of NF-Kappa B may contribute to the onset of Migraines.

  [5]

Schizophrenia

 

 

 

Elevated NF-κB has also been associated with schizophrenia.

  [6]

In order to quell chronic inflammation, it is important to inhibit elevated levels of NF-κB.

Table: Nootropics/Nutraceuticals/Foods/Herbs that Inhibit Elevated Levels of NF-Kappa B*

 NF-Kappa B

 

 

Category

Nootropics/Nutraceuticals/Foods/Herbs

Reference(s)

Algae

 

 

 

Chlorella

  [7]

Foods

 

 

 

Blueberries

  [8]

Amino Acids

 

 

 

N-Acetyl-Cysteine (NAC)

  [9]   10]

Carotenoids

 

 

 

Lutein

  [11]

Herbs

 

 

 

Andropgraphis

  [12]

 

Ashwagandha

  [13]

 

Astragulus

  [14]

 

Boswellia serrata

  [15]   [16]

 

Cat’s Claw

  [17]

 

Green Tea

  [18]   [19]

 

Horse Chestnut

  [20]

 

Jiaogulan

  [21]

 

Korean Ginseng

  [22]

 

Magnolia

  [23]

 

Milk Thistle

  [24]

 

Nettle

  [25]

Hormones

 

 

 

Melatonin

  [26]

Lipids

 

 

 

Guggulsterones

  [27]

Minerals

 

 

 

Selenium

  [28]    [29]

 

Zinc

  [30]

Peptides

 

 

 

Glutathione

  [31]

Polyphenols

 

 

 

Apigenin

  [32]

 

Caffeic Acid Phenethyl Ester

  [33]

 

Curcumin

  [34]

 

Epigallo-Catechin-Gallate

  [35]

 

Hesperidin

  [36]

 

Luteolin

  [37]

 

Pycnogenol

  [38]

 

Quercetin

  [39]

 

Resveratrol

  [40]  [41]

 

Silymarin

  [42]

Vitamins

 

 

 

Alpha Lipoic Acid

  [43]

 

Vitamin A

  [44]

 

Vitamin B6

  [45]

 

Vitamin C

  [46]

 

Vitamin D

  [47]  [48]

 

Vitamin E

  [49]

*Note: The contents of this document have not been evaluated by the Food and Drug Administration. Any substances referred to in this document are not intended to diagnose, treat, cure, or prevent any disease. Information and statements made are for education purposes and are not intended to replace the advice of your treating doctor. BioFoundations does not dispense medical advice, prescribe, or diagnose illness. If you have a severe medical condition or health concern, consult your physician.


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