Modified Citrus Pectin

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Modified Citrus Pectin is a pH-altered form of Citrus Pectin composed of smaller (than regular Citrus Pectin), non-branching Carbohydrate chains. Its therapeutic effects are different compared to (non-modified) Citrus Pectin.

Pectin in its natural form cannot be absorbed by the body and is considered a type of undigestible soluble dietary fiber, whereas modified citrus pectin has a reduced molecular weight compared to regular citrus pectin, is mostly linear homogalacturonanic acid, and rich in galactose residues, which are easily processed by the digestive system and absorbed into the bloodstream.

Modified Citrus Pectin is produced from Citrus Pectin derived from the peel and pulp of Citrus Fruits via pH and temperature modifications that break Citrus Pectin into short, non-branched, high-Galactose-content Carbohydrate chains. These shorter chains are more water-soluble and are significantly more bioavailable to the human body compared with regular Citrus Pectin.

Chelating Effects of Modified Citrus Pectin

A pilot trial evaluating MCP’s chelating effects provided evidence that orally administered MCP significantly increases urinary excretion of toxic metals. In a study published in 2006, 8 healthy individuals were given 15 grams of MCP daily for 5 days and 20 grams of MCP on day 6. Twenty-four hour urine samples were collected on days 1 and 6 and analyzed for toxic and essential elements. The investigators reported that significant urinary excretion of arsenic, mercury, cadmium, and lead increased within 1 to 6 days of MCP treatment. There was a 150% increase in cadmium excretion and 560% increase in lead excretion on day 6 (Eliaz 2006). Essential minerals such as calcium, zinc, and magnesium were not noted to increase in the urinary analysis, indicating that MCP treatment did not deplete these nutrients.

In a case study report, 5 patients with different illnesses were given either MCP alone or in combination with alginate (MCP/alginate complex) for up to 7 months. Each one had a gradual decrease of total heavy metal burden, which is believed to have played an important role in the patients’ recovery and health maintenance. The patients had a 74% average decrease in toxic heavy metals after treatment. This is the “first known documentation of evidence” of a possible correlation between positive clinical outcomes and a reduction of toxic heavy metal load using MCP alone or as an MCP/alginate complex. Authors recommended “further studies be performed to confirm the effectiveness of this gentle non-toxic chelating system as an alternative to harsher chelators in the treatment of patients with a heavy metal body burden.”  [1]


References:

[1] Eliaz I, Weil E, Wilk B. Integrative medicine and the role of modified citrus pectin/alginates in heavy metal chelation and detoxification–five case reports. Forsch Komplementmed. 2007 Dec;14(6):358-64

Effect of citrus pectin on blood lipids and fecal steroid excretion in man

PectaSol-C Modified Citrus Pectin Induces Apoptosis and Inhibition of Proliferation in Human and Mouse Androgen-Dependent and- Independent Prostate Cancer Cells

Modified citrus pectin (MCP) increases the prostate-specific antigen doubling time in men with prostate cancer: a phase II pilot study

Inhibition of Spontaneous Metastasis in a Rat Prostate Cancer Model by Oral Administration of Modified Citrus Pectin

Inhibitory effect of modified citrus pectin on liver metastases in a mouse colon cancer model

Modified citrus pectin anti-metastatic properties: one bullet, multiple targets

MODIFIED CITRUS PECTIN SLOWS PSA DOUBLING TIME: A Pilot Clinical Trial

Effects of daily oral administration of quercetin chalcone and modified citrus pectin on implanted colon-25 tumor growth in Balb-c mice

Inhibition of Cancer Cell Growth and Metastases – Nutrition Review

The Health Benefits of Modified Citrus Pectin


PDF Information References:

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Integrative Medicine and the Role of Modified Citrus Pectin/Alginates in Heavy Metal Chelation and Detoxification – Five Case Reports

Modified Citrus Pectin


Informational References:

American Cancer Society – Modified Citrus Pectin

Memorial Sloan_Kettering Cancer Center – Modified Citrus Pectin


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