Matrix Gla protein: The Calcification Inhibitor


Matrix gamma-carboxylated glutamate (GLA) protein (MGP) is a protein found in numerous body tissues, including the bones, heart, kidney and lungs.

Matrix Gla Protein is a calcification inhibitor which assists to prevent calcification of the arteries. Increasing Matrix Gla Protein production in the arteries may assist in the prevention Atherosclerosis. [1]

Matrix Gla protein requires Vitamin K for optimum function. [2]

Vitamin A and D3 stimulates the production of Matrix Gla protein. [3]


[1]  Bostrom, K., et al. Insights into the mechanism of vascular calcification. Am J Cardiol. 88(2A):20E-22E, 2001

Shearer,. M. J. Role of vitamin K and Gla proteins in the pathophysiology of osteoporosis and vascular calcification. Curr Opin Clin Nutr Metab Care. 3(6):433-438, 2000

[2]  Garber, A. K., et al. Comparison of phylloquinone bioavailability from food sources or a supplement in human subjects. Journal of Nutrition. 129(6):1201-1203, 1999

[3] Cancela, M. L., et al. Retinoic acid induces matrix Gla protein gene expression in human cells. Endocrinology. 130(1):102-108, 1992

Price, P. A. Gla-containing proteins of bone. Connect Tissue Res. 21(1-4):51-57, 1989

Matrix Gla-protein: the calcification inhibitor in need of vitamin K

The Role of Vitamin K in Soft-Tissue Calcification

Vitamin K-dependent carboxylation of matrix Gla-protein: a crucial switch to control ectopic mineralization

Retinoic acid induces matrix Gla protein gene expression in human cells

Gla-containing proteins of bone

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