Long-Term Potentiation (LTP)

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In neuroscience, long-term potentiation (LTP) is a persistent strengthening of synapses based on recent patterns of activity. These are patterns of synaptic activity that produce a long-lasting increase in signal transmission between two neurons. The opposite of LTP is long-term depression which produce long-lasting decrease in synaptic strength.

It is one of several phenomena underlying synaptic plasticity, the ability of chemical synapses to change their strength.

As memories are thought to be encoded by modification of synaptic strength, LTP is widely considered one of the major cellular mechanisms that underlies learning and memory.

There are a number of substances that have been studied and researched for their ability to enhance long-term potentiation.  These substances are listed in the Table below:

Substances the Enhance Long-Term Potentiation

Long Term Potentiation  
CategoryNutraceuticals/Foods/HerbsReferences
Alkaloids
Berberine1
Amino Acids
Taurine2
Foods
Artichoke3
Herbs
Artichoke Extract4 Stacked with Forskolin
Uncaria Tomentosa5 Cat’s Claw
Ashwagandha6
Korean Ginseng7 Gintonin
Hormones
Melatonin8
Krebs Cycle Chemical
Oxaloacetate9 10
Lipids
Forskolin11
Polyphenols
Fisetin12
Vitamins
Alpha Lipic Acid13


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