In neuroscience, long-term potentiation (LTP) is a persistent strengthening of synapses based on recent patterns of activity. These are patterns of synaptic activity that produce a long-lasting increase in signal transmission between two neurons. The opposite of LTP is long-term depression which produce long-lasting decrease in synaptic strength.
It is one of several phenomena underlying synaptic plasticity, the ability of chemical synapses to change their strength.
As memories are thought to be encoded by modification of synaptic strength, LTP is widely considered one of the major cellular mechanisms that underlies learning and memory.
There are a number of substances that have been studied and researched for their ability to enhance long-term potentiation. These substances are listed in the Table below:
Substances the Enhance Long-Term Potentiation
Long Term Potentiation Category Nutraceuticals/Foods/Herbs References
Alkaloids Berberine 1
Amino Acids Taurine 2
Foods Artichoke 3
Herbs Artichoke Extract 4 Stacked with Forskolin
Uncaria Tomentosa 5 Cat’s Claw
Korean Ginseng 7 Gintonin
Hormones Melatonin 8
Krebs Cycle Chemical Oxaloacetate 9 10
Lipids Forskolin 11
Polyphenols Fisetin 12
Vitamins Alpha Lipic Acid 13
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