Lactobacillus reuteri NCIMB 30242 is a Heart Healthy Probiotic


Lactobacillus reuteri is a Gram-positive bacterium that is naturally found in the microbiome and is considered one of the most ubiquitous members of the naturally occurring gut bacteria.

Lactobacillus reuteri NCIMB 30242 or LRC™ is a unique superstrain of Lactobacillus reuteri that was initially developed by Micropharma Limited based in Canada.  In 2014, the U.S. company UAS Laboratories acquired the rights of this superstrain probiotic from Micropharma Limited.

Lactobacillus reuteri NCIMB 30242 is the first clinically proven heart health probiotic.  1

Clinical trials have been conducted with Lactobacillus reuteri NCIMB 30242 and the results were very promising for cardiovascular health.  The health benefits of Lactobacillus reuteri NCIMB 30242 include:

  • Supports healthy cholesterol already within normal range by reducing total cholesterol and LDL cholesterol
  • Supports healthy LDL particle size by supporting healthy apoB-100 (a marker for LDL particle number)
  • Promotes a healthy inflammatory response by supporting healthy C-reactive protein
  • Maintains healthy fibrinogen levels, helping to prevent blood clot formation
  • Supports and increases vitamin D levels (25-hydroxyvitamin D)
How L. Reuteri Helps The Body

Figure 1.  How L. Reuteri Helps the Body  (Source:  Life Extension Foundation: Unique Probiotic Targets Cardiovascular Disease)

Supports Healthy Total and LDL Cholesterol

In clinical trials, Lactobacillus reuteri NCIMB 30242 demonstrated an ability to support healthy cholesterol in adults already within the normal range.  2

It supports healthy total cholesterol and LDL-cholesterol levels in two ways:

  • By supporting the natural elimination of cholesterol, and
  • By helping to maintain the normal amount of cholesterol the body produces

Lactobacillus reuteri NCIMB 30242 produces an enzyme called bile salt hydrolase.  This enzyme breaks apart bile acids which are natural detergents made by the liver from cholesterol.  3  4

Supports Healthy LDL Particle Size

The size of LDL particles is governed by and influenced by a lipoprotein called apoB-100.  The particle size of LDL is critical to maintaining heart health.

Lactobacillus reuteri NCIMB 30242 has been shown to support healthy apoB-100 levels, which in turn may help to maintain healthy LDL particle size.  5

In one study of adults with elevated cholesterol, apoB-100 fell by 8% after consuming Lactobacillus reuteri NCIMB 30242.  6

Supports Healthy C-reactive protein (CRP) Levels

C-reactive protein (CRP) is a sensitive marker of inflammation that is used by medicine as a predictor of overall cardiovascular health. Lactobacillus reuteri NCIMB 30242 has been shown to support healthy CRP levels.  7

Maintains Healthy Fibrinogen Levels

Lactobacillus reuteri NCIMB 30242 has been shown to support healthy fibrinogen levels.  8

Increases Mean Circulating 25-hydroxyvitamin D

Oral supplementation with probiotic Lactobacillus reuteri NCIMB 30242 increases mean circulating 25-hydroxyvitamin D.  Lactobacillus reuteri NCIMB 30242 increased serum 25-hydroxyvitamin D by 14.9 nmol/L, or 25.5%, over the intervention period, which was a significant mean change relative to placebo of 17.1 nmol/L, or 22.4%, respectively (P = .003).  9  

Informational References:

UAS Labs