L-Citrulline May Reverse the Progression of Atherosclerosis and Detoxifies Ammonia


The organic compound l-citrulline is an α-amino acid and is considered non-essential.  It is an amino acid that participates in and is a key intermediate in the important Urea cycle which is the pathway by which mammals excrete ammonia.

The rind of watermelon (Citrullus lanatus) is the highest source of l-citrulline.  Garlic and onions also have some trace amounts of l-citrulline.   Due to the fact that these food sources have little amounts of l-citrulline, it is necessary to consume a l-citrulline supplement to achieve the therapeutic effects. 

L-Citrulline is an amino acid that plays an important role in nitric oxide metabolism and regulation.  L-Citrulline is converted to L-Arginine in the body to support L-Arginine and nitric oxide levels.  Increased production of nitric oxide (NO) promotes vascular dilation which improves oxygen and blood circulation throughout the body.  

The ingestion of l-citrulline can abrogate the state of oxidative stress and reverse the progression of atherosclerosis. This approach may have clinical utility in the treatment of atherosclerosis in humans.   1

L-citrulline malate stimulates hepatic ureogenesis and favorizes the renal reabsorption of bicarbonates. These metabolic actions had a protective effect against acidosis and ammonia poisoning and explain the anti-fatigue properties of citrulline malate in man.   2

Malic acid is commonly combined with l-citrulline in supplement form.  Malic acid is a superior alpha hydroxy acid for the elimination of aluminum from the body.  In a study that compared the efficacies of nine chelating agents on the toxicity of aluminum in mice, malic and succinic acids demonstrated the most effectiveness in chelating aluminum from the body. 3

L-Citrulline Webinar Kyowa Hakko