L-alanyl-l-glutamine: Sustamine®


Sustamine is a revolutionary dipeptide that combines pure L-Glutamine and L-Alanine to create an ingredient that is more effective than Glutamine alone for rehydration and recovery.*

Sustamine enhances electrolyte and water absorption in the intestines.* It also stimulates glycogen synthesis, inhibits muscle protein breakdown and promotes the synthesis of muscle protein.* Sustamine has also been shown to help protect the integrity of the gastrointestinal tract, contributing to better nutrition absorption.*

A dipeptide is a bonded chain of two amino acids, in this case. L-Glutamine and L-Alanine.  Much smaller than a complete protein, a dipeptide can be transported directly into intestinal cells.  The muscles get nutrients faster because dipeptides are more efficiently absorbed.

Research shows that a combination of L-Alanine with L-Glutamine is more effective than Glutamine alone for increasing electrolyte and water absorption lost during exercise. L-Glutamine is also the most important amino acid for stimulating muscle protein synthesis, while L-Alanine is an amino acid needed for rebuilding glycogen stores in the body.  1


Sustamine Infographic (Source: www.sustamine.com)

There have been a number of scientific studies on Sustamine®:

Examination of the efficacy of acute Sustamine® L-Alanyl-L-Glutamine during Hydration Stress in Endurance Exercise

Hoffman JR, Ratamess NA, Kang J, et al. Examination of the efficacy of acute L-alanyl-L-glutamine ingestion during hydration stress in endurance exercise. Journal of the International Society of Sports Nutrition. 2010;7:8. doi:10.1186/1550-2783-7-8.

Sustamine® Maintains Performance Levels For Collegiate Basketball Players, Study Shows

Hoffman JR, Williams DR, Emerson NS, et al. L-alanyl-L-glutamine ingestion maintains performance during a competitive basketball game. Journal of the International Society of Sports Nutrition. 2012;9:4. doi:10.1186/1550-2783-9-4.

Sustamine® absorbs from gut to blood better than glutamine alone

Harris RC, Hoffman JR, Allsopp A, Routledge NB. L-glutamine absorption is enhanced after ingestion of L-alanylglutamine compared with the free amino acid or wheat protein. Nutr Res. 2012 Apr;32(4):272-7. doi: 10.1016/j.nutres.2012.02.003. Epub 2012 Apr 9.

Sustamine® taken post exercise might reduce muscle protein breakdown after resistance exercise

Wang W, Choi RH, Solares GJ, Tseng HM, Ding Z, Kim K, Ivy JL. L-Alanylglutamine inhibits signaling proteins that activate protein degradation, but does not affect proteins thatactivate protein synthesis after an acute resistance exercise. Amino Acids. 2015 Jul;47(7):1389-98. doi: 10.1007/s00726-015-1972-7. Epub 2015 Apr 3.

Sustamine® L-Alanyl-L-Glutamine during endurance exercise appears to enhance athletes’ reaction times when compared to no hydration

Pruna GJ, Hoffman JR, McCormack WP, et al. Effect of acute L-Alanyl-L-Glutamine and electrolyte ingestion on cognitive function and reaction time following endurance exercise. Eur J Sport Sci 2014 Oct 16:1-8.

Study Shows Taking Sustamine® L-Alanyl-L-Glutamine During Strenuous Exercise May Ward Off Exhaustion

McCormack WP, Hoffman JR, Pruna GJ, Jajtner AR, Townsend JR, Stout JR, Fragala MS, Fukuda DH. Effects of l-Alanyl-l-Glutamine Ingestion on One-Hour Run Performance. J Am Coll Nutr. 2015 Jun 22:1-9.

Informational References:


Sustamine® Brochure

Performance Matters: Benefits of Sustamine L-Alanyl-L-Glutamine – Video

Danielle Citrolo, PharmD, on the benefits of Sustamine – Video


Swanson Health Products – Sustamine®

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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