Japanese Natto Extends the Adult Lifespan of Caenorhabditis elegans


Researchers at the Tsukuba International University in Japan investigated the effects of a water extract of natto on the aging of the nematode Caenorhabditis elegans. 

Caenorhabditis elegans is a popular animal model for the study of aging and longevity.   Caenorhabditis elegans has a short life cycle and its life span is around 2 to 3 weeks under suitable living conditions.  Compared to the use of other model organisms such as mice, the short life cycle of Caenorhabditis elegans reduces the experimental cycle and facilitates biological study.

Figure 1:  Caenorhabditis elegans

The scientists used a water extract of Japanese natto and found through their experiments that had beneficial anti-aging effects in vivo based on two conclusions:  1

  • Prolonged  the adult lifespan of the wild-type worms and rendered them resistant to oxidative and thermal stress, exerting antioxidative effects
  • Natto extract significantly delayed the accumulation of lipofuscin



Cover Photo Credits:  Image by Tamaki Sono (Flickr)

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