Inositol hexaphosphate (IP6) + Inositol: Potential Cancer Inhibition

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Inositol hexaphosphate (IP6) (hereinafter “IP6”), is a natural carbohydrate molecule present in most plant and animal cells, primarily cereals, grains, legumes and meat.   IP6 can also be made in the human body from inositol.

The function of IP6 in the human body is the regulation of numerous intracellular functions:

  • Signal transduction
  • Cell growth and differentiation
  • Platelet function
  • Cholesterol metabolism

IP6 has shown striking anticancer effects in different experimental models. Inositol has also been found to possess moderate anticancer activity.

An important study published in The Journal of Nutrition in November 2003 examined the cancer inhibition potential of IP6 and Inositol.  According to the study:

the most consistent and best anticancer results were obtained from the combination of IP6 plus inositol.  In addition to reducing cell proliferation, IP6 increases differentiation of malignant cells, often resulting in a reversion to normal phenotype.”   1

The study further states that:

“IP6 holds great promise in our strategies for the prevention and treatment of cancer. IP6 plus inositol enhances the anticancer effect of conventional chemotherapy, controls cancer metastases, and improves the quality of life, as shown in a pilot clinical trial. The data strongly argue for the use of IP6 plus inositol in our strategies for cancer prevention and treatment. However, the effectiveness and safety of IP6 plus inositol at therapeutic doses needs to be determined in phase I and phase II clinical trials in humans.”   2

As hypothesized, it was demonstrated that IP6 is a broad-spectrum antineoplastic agent, affecting different cells and tissue systems. IP6 inhibited the growth of all tested cell lines in a dose- and time-dependent manner.  In vitro studies with IP6 are summarized in Table 1.

TABLE 1

Antitumor effect of inositol hexaphosphate (IP6) in vitro

Organ or tissue Species Cell line Investigator
Blood Human Erythroleukemia Shamsuddin et al. (26)
K562 cell line
K562 + human bone marrow Deliliers et al. (27)
Colon Human Adenocarcinoma Sakamoto et al. (28)
HT-29 cell line Yang & Shamsuddin (29)
Lung Rat Tracheal epithelium + B[a]P Arnold et al. (30)
Liver Human HepG2 cells Vucenik et al. (31)
Mammary Human Adenocarcinoma Shamsuddin et al. (32)
MCF-7, MDA-MB 231 cells
Uterine cervix Human HeLa cells Ferry et al. (25)
Prostate Human Adenocarcinoma Shamsuddin & Yang (33)
PC-3 cell line
Human DU145 cells Zi et al. (15)
Singh et al. (34)
Skin Mouse JB6 cells Huang et al. (35)
Mouse HEL-30 cells Nickel & Belury (36)
Soft tissue Mouse 3T3 fibroblast Babich et al. (37)
Human Rhabdomyosarcoma, RD cells Vucenik et al. (38)

(Source:  Cancer Inhibition by Inositol Hexaphosphate (IP6) and Inositol: From Laboratory to Clinic J. Nutr. November 1, 2003 vol. 133 no. 11 3778S-3784S)

A summary of in vivo studies using IP6 and inositol is shown in Table 2.

TABLE 2

Antitumor effect of IP6 and inositol in vivo

Organ/Tissue Species Disease parameter Mode Investigator
Colon Mouse Carcinoma in drink Shamsuddin et al. (19)
Rat Carcinoma in drink Shamsuddin et al. (18,20)
Rat Carcinoma in drink Ullah & Shamsuddin (40)
Rat Carcinoma in diet Nelson et al. (41)
Rat Carcinoma in diet Shivapurkar et al. (42)
Rat Carcinoma in diet Pretlow et al. (43)
Rat Carcinoma in diet Challa et al. (44)
Rat Carcinoma in diet Jenab & Thompson (45)
Mouse Cell proliferation in diet Thompson & Zhang (46)
Liver Rat Hepatocellular Ca in diet Hirose et al. (47)
HepG2 cell line intratumoral Vucenik et al. (48)
Lung Mouse Pulmonary adenoma in diet Estensen & Wattenberg (49)
Wattenberg (50)
Mammary Rat Carcinoma in drink Vucenik et al. (51,52,53)
Rat Carcinoma in diet Shivapurkar et al. (42)
Hirose et al. 1994 (54)
Mouse Cell proliferation in diet Thompson & Zhang (46)
Skin Mouse Papilloma two-step in drink Ishikawa et al. (55)
initiat→promotion in drink
Soft Tissue Rat Fibrosarcoma in diet Jariwalla et al. (56)
Transplanted 12% Mg
Mouse Fibrosarcoma i.p. Vucenik et al. (39)
Trans + Metast
Human Rhabdomyosarcoma peritumoral Vucenik et al. (38)
RD cell line

(Source:  Cancer Inhibition by Inositol Hexaphosphate (IP6) and Inositol: From Laboratory to Clinic J. Nutr. November 1, 2003 vol. 133 no. 11 3778S-3784S)


Informational References:

IP-6 Research, Inc.


Resources:

Jarrow Formulas, IP6, Inositol Hexaphosphate

Jarrow Formulas, Inositol, Powder

Dr. Shamsuddin’s Original IP-6 IP6 Gold Immune Support Original Formula with IP6 & Inositol

Cell Forte IP-6 & Inositol

Natural Factors, IP6 & Inositol


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