Inositol hexaphosphate (InsP6 or IP6) up-regulates tumor suppressor gene p53 and WAF1 gene expression


Inositol hexaphosphate (InsP6 or IP6) an organic Acid composed of one molecule of the myoinositol form of Inositol joined with six phosphorus molecules (i.e. it is the hexaphosphate ester of Inositol). 

IP6 has a novel anti-cancer action both in vivo and in vitro. IP6 inhibits cell growth, decreases cell proliferation and also causes differentiation of various cell lines, including HT-29 human colon carcinoma cell.

Tumor Suppressor Genes code for endogenous proteins that inhibit cell division and this inhibition of cell division is involved in the prevention and regression of cancer.

Tumor protein p53, also known as p53 or tumor suppressor gene p53, prevents cancer formation, thus, functions as a tumor suppressor.  As such, p53 has been described as “the guardian of the genome” because of its role in conserving stability by preventing genome mutation.

The healthy objective is to always up-regulate and increase the expression of p53 (in other words, turn “on” p53), in order to inhibit cancer formation.

According to a study published in the May-June 1998 edition of the Anticancer Journal, IP6 increases expression of the tumor suppressor gene p53 by up to 17-fold.  1

The study investigated the effects of IP6 on the expression of p53 and WAF1/p21 in HT-29 human colon carcinoma by immunocytochemistry and quantitative ELISA. Our immunocytochemical studies with anti p53 antibodies (wild type-PAb246 and PAb1620) and anti p21waf1/cip1 (EA10) antibodies demonstrated an increased level of p53 and p21waf1/cip1 after 3 and 6 days of treatment with 3.3 and 5 mM IP6. Quantitative assay for p53 and p21waf1/cip1 by ELISA did not show detectable levels in untreated control cells, while strong expression of p53 and p21waf1/cip1 protein by 3.3 and 5 mM IP6 was seen on day 3 and day 6 of treatment.  2

The data from the study demonstrated that IP6 up-regulates the expression of the tumor suppressor gene p53 and p21WAF1/CIP1 gene and their modulation may be one of the mechanisms of the anti-neoplastic action of IP6.  3


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