Increasing Intracellular Glutathione


The antioxidant glutathione, known as GSH, is arguably the most important antioxidant the body makes, and most certainly the most powerful intracellular antioxidant. In its reduced form it plays a pivotal role in DNA repair, immunity, flushing of toxins, removal of heavy metals, quenching of free radicals, and recycling of other antioxidants such as vitamins C and E.

Glutathione supports detoxification in the lining fluid of the lung and intestines, enhances macrophage function, and virus production.

Unfortunately, oral supplementation of glutathione has proved tricky and sometimes ineffective, since the molecule when taken orally is not able to effectively reach and be absorbed into the intracellular space where it is needed.

In order to resolve the problematic issue of poor bioavailability of oral glutathione, there are various forms of glutathione that provide greater bioavailability.

Forms of Glutathione:

  • Intravenous Glutathione – excellent bioavailability. Requires a medical doctors prescription and administration from a qualified health care professional.
  • Glutathione Transdermal Cream – excellent bioavailability. Requires a medical doctors prescription. Daily self-administration onto skin.
  • Liposomal Glutathione – considered good to excellent bioavailability. Non-prescription.
  • S-Acetyl-Glutathione – considered good to excellent bioavailability. It crosses the cell membrane more easily than GSH itself, and is easily de-acetylated in the cell, becoming active GSH. The fact that S-GSH can be effectively absorbed by cells after an oral dose argues for its great potential in comparison to IV therapy.
  • Precursors to Glutathione – these are substances that have been shown to increase glutathione content within the cell.
    • N-Acetyl-Cysteine
    • D-ribose-L-cysteine
    • Glutamine
    • S-Adenosyl methionine (SAMe)
    • Whey Protein (bioactive and non-denatured)
    • Melatonin
    • Alpha Lipoic Acid
    • Silymarin (Milk Thistle)
    • Selenium
    • Vitamin C (recycles glutathione)
    • Vitamin E (recycles glutathione)
    • Vitamin D3
    • Curcumin
    • Sulfur in the form of MSM
    • Sulfur Rich Foods
      • Garlic
      •  Onions
      •  Cruciferous vegatables
    •  Taurine

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