High-mobility group protein 1 (HMG-1): A Marker of Chronic Inflammation


High-mobility group protein 1 (HMG-1) is a protein that in humans is encoded by the HMGB1 gene.

HMGB1 turns on the release of chemical signals called cytokines that generate inflammation in your body.

The molecule HMGB1 is responsible for initiating acute inflammation, which is a helpful reaction when your body is under attack by germs, or following an injury. Unfortunately, when a cell is damaged, its contents of HMGB1 leak out, leading to chronic inflammation.

When HMGB1 leaks out, it acts as a “danger signal” that triggers the release of chemical signaling molecules (called cytokines) that call in more white blood cells, which release still more cytokines, in a vicious cycle.

Inhibiting HMGB1 is a powerful means of slowing and reversing the processes involved in inflammation.

HMGB1 serves as a risk factor for memory impairment, chronic neuro-degeneration, and progression of neuro-inflammation. 1

The Table below lists the recognized and researched substances that may inhibit High-mobility group protein 1 (HMG-1):

Substances that Inhibit HMGB1

Mung Bean Coat Extract1 2 vitexin, isovitexin
Green Tea4 5 6 7
Angelica sinensis (Dong Quai)8
Glycyrrhizin (Licorce)9


Life Extension Cytokine Suppress with EGCG