Geroprotectors: Agents for Prolonging the Lifespan of Animals

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A geroprotector is one of the five different types of senotherapeutic strategies that aims to affect the root cause of aging and age-related diseases, and thus prolong the life span of animals.  Geroprotectors utilize agents and strategies which prevent or reverse the senescent state by preventing triggers of cellular senescence, including:

  • DNA damage
  • Oxidative stress
  • Proteotoxic stress
  • Telomere shortening

Senotherapeutics refers to therapeutic agents and strategies that specifically target cellular senescence and include any of the following therapies:

  • Gene therapy
  • Geroprotectors
  • Immune clearance of senescent cells
  • SASP inhibitors
  • Senolytics

An excellent and resourceful database of current geroprotectors is Geroprotectors.org.

According to the geroprotectors website, the purpose of the database is described:

“The Geroprotectors.org database comprises more than 250 life-extension experiments in 11 wild-type model organisms (including M. musculus and C. elegans, among others). We gathered data about more than 200 chemicals promoting longevity, including compounds approved for human use. This database integrates information about lifespan-increasing experiments and related compounds, suppression of aging mechanisms, activation of longevity mechanisms and age-related diseases obtained from research papers and databases.

Geroprotectors.org is intended as a tool for accelerating the process of identifying geroprotectors from a variety of existing substances through pharmacological modeling and biostatistical analysis to reveal new substances with geroprotective effects.”

They further define a geroprotector as follows:

“A “geroprotector” is any intervention that aims to increase longevity, or that reduces, delays or impedes the onset of age-related pathologies by hampering aging-related processes, repairing damage or modulating stress resistance.”

Examples of various geroprotectors from the database include:

  • Baicalein  1
  • Berberine  2
  • Carnosine  3
  • Glutathione  4

Informational References:

Geroprotectors.org


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