Creatine significantly lowers accumulation of Lipofuscin


Lipofuscin is a fine granular yellow-brown pigment composed of lipid containing residues of lysosomal (waste) digestion. 

Lipofuscin is normally found in the following organs:

  • Kidney
  • Heart
  • Liver
  • Retina
  • Skin
  • Adrenals
  • Neurons
  • Ganglion cells

The accumulation of lipofuscin is considered a “marker of aging”.

A study published in Amino Acids in May 2011 concluded that:

“In brains of creatine-treated mice, there was a trend toward a reduction of reactive oxygen species and significantly lower accumulation of the “aging pigment” lipofuscin.”

The authors further state that:

“These data showed that creatine improves health and longevity in mice. Creatine may, therefore, be a promising food supplement to promote healthy human aging. However, the strong neuroprotective effects in animal studies of creatine have not been reproduced in human clinical trials (that have been conducted in Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis).”


Klopstock T, Elstner M, Bender A. Creatine in mouse models of neurodegeneration and aging. Amino Acids. 2011 May;40(5):1297-303.

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