Aging in characterized by a number of conditions and factors. Some of these conditions and factors include:
- Decline of mitochondrial membrane function
- Ambulatory activity
- Decline in memory
- Age-associated mitochondrial structural decay
- Free radical-induced lipid peroxidation
The National Academy of Sciences (NAS) is a private non-profit organization in the United States. It was founded in 1863 as a result of an Act of Congress that was approved by Abraham Lincoln.
The National Academy of Sciences studied the effects of acetyl-L-carnitine and lipoic acid on aging and found that the factors listed above could be partially reversed with their combined consumption. They published three separate studies confirming the benefit of combining acetyl-L-carnitine and lipoic acid in controlling some of the conditions and factors of aging.
This animal study demonstrated that the combination of acetyl-L-carnitine and lipoic acid improved ambulatory activity and a partial reversal of the decline of mitochondrial membrane function while consumption of oxygen significantly increased. 1
This animal study showed that supplementation with acetyl-L-carnitine and lipoic acid resulted in improved memory in old rats. Acetyl-L-carnitine and lipoic acid reversed age-associated mitochondrial structural decay in the hippocampus region of the brain. 2
In the third study, the authors tested whether the dysfunction with age of carnitine acetyltransferase (CAT), a key mitochondrial enzyme for fuel utilization, is due to decreased binding affinity for substrate and whether this substrate, fed to old rats, restores CAT activity. The kinetics of CAT were analyzed by using the brains of young and old rats and of old rats supplemented for 7 weeks with the CAT substrate acetyl-l-carnitine (ALCAR) and/or the mitochondrial antioxidant precursor R-alpha-lipoic acid (LA). Feeding ALCAR or ALCAR plus LA to old rats significantly restored CAT-binding affinity for ALCAR and CoA, and CAT activity.
Supplementation also inhibited free radical-induced lipid peroxidation, which enhanced the activity of the energy-producing enzyme in the mitochondria.
Thus, feeding old rats high levels of key mitochondrial metabolites can ameliorate oxidative damage, enzyme activity, substrate-binding affinity, and mitochondrial dysfunction. 3
To purchase acetyl-l-carnitine and R-lipoic acid visit: Geronova Research