Celery Seeds provides Multiple Health Benefits

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Celery (Apium graveolens) is a cultivated plant commonly used as a vegetable. Celery is also grown exclusively to produce celery seeds, which are used as a spice in some parts of the world.  Celery seeds are also used to manufacture nutraceuticals that contain the main active ingredient, 3-n-butylphthalide.

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Celery plant

The active compounds in celery seeds are:

  • Butylphthalide (3-n-butylphthalide or NBP or 3nB) 
  • Sedanolide
  • Apiin and
  • Apigenin
  • d-limonene,
  • p-mentha-2,8-dien–ol, p-mentha-8(9)-en-1,2-diol

The 3nB extract of celery seeds have been studied and recognized for its treatment of hypertension.  Animal and lab studies reveal that 3nB-rich extracts of celery seeds produce blood pressure reductions of up to 38 mm Hg in hypertensive rats (this effect was not seen in those with normal blood pressures).

In 2004, a synthetic form of 3nB was approved in China for the treatment of cerebral ischemia and mild cognitive impairment as well as for the prevention of Alzheimer’s disease.

The health benefits of celery seeds go well beyond the cardiovascular benefits.  The Table below lists some of the other health benefits of celery seeds.

Table:  Health Benefits of Celery Seeds

Celery Seeds

 

 

 

Biosystem

Condition

Benefit

Reference

Cardiovascular

 

 

 

 

Hypertension

 

 

 

 

Celery seeds may lower blood pressure

 [1]

 

Blood circulation

 

 

 

 

Celery seed may improve blood circulation due to 3-n-Butyl-Phthalide

 

 

Antiplatelet and Antithrombotic

 

 

 

 

Antiplatelet and antithrombotic activity of L-3-n-butylphthalide in rats.

 [2]

 

Vasodilator

 

 

 

 

Vasodilatory action mechanisms of apigenin isolated from Apium graveolens in rat thoracic aorta.

 [3]

Immune System

 

 

 

 

 

 

 

 

Anti-Inflammatory

 

 

 

 

Celery seed extract having anti-inflammatory activity

 [4]

 

Helicobacter pylori

 

 

 

 

May kill helicobacter pylori

 [5]

 

Liver cancer

 

 

 

 

May help to prevent liver cancer

 [6]

 

Chemoprevention

 

 

 

 

Chemoprevention of benzo[a]pyrene-induced stomach cancer.  The data indicating that 3-n-butyl phthalide and sedanolide were both active in tumor inhibition and GST assays suggested a correlation between the inhibitory activity and the GST-inducing ability

 [7]

Musculoskeletal System

 

 

 

 

Gout

 

 

 

 

May alleviate gout

 [8]

 

Rheumatism

 

 

 

 

May alleviate rheumatism

 [9]

Neurological

 

 

 

 

Stroke

 

 

 

 

Dl-3-n-butylphthalide (NBP), first isolated from the seeds of celery, showed efficacy in animal models of stroke

 [10]  [11]

 

Vascular Dementia

 

 

 

 

Protective effects of dl-3-n-butylphthalide on changes of regional cerebral blood flow and blood-brain barrier damage following experimental subarachnoid hemorrhage

 [12]

 

Cerebral hypoperfusion

 

 

 

 

l-3-n-Butylphthalide improves cognitive impairment induced by chronic cerebral hypoperfusion in rats.

 [13]

 

Tau phosphorylation

 

 

 

 

L-3-n-butylphthalide reduces tau phosphorylation and improves cognitive deficits in AbetaPP/PS1-Alzheimer’s transgenic mice.

 [14]

 

Amyotrophic lateral sclerosis

 

 

 

 

“Dl-3-n-butylphthalide extends survival by attenuating glial activation in a mouse model of amyotrophic lateral sclerosis”.

 [15]

 

Brain ischemia

 

 

 

 

3-n-butylphthalide (NBP) attenuated neuronal autophagy and amyloid-beta expression in diabetic mice subjected to brain ischemia

 [16]

 

Parkinson’s disease

 

 

 

 

Dl-3-n-butylphthalide, a natural antioxidant, protects dopamine neurons in rotenone models for Parkinson’s disease

 [17]


References:


[1] http://www.hypertensioninstitute.com/wp-content/uploads/2009/08/nutraceuticals_vitamins_and_antioxidants_in_hyptertension_treatment.pdf

Heyen BJ, Alsheikh MK, Smith EA, Torvik CF, Seals DF, Randall SK. The calcium-binding activity of a vacuole-associated, dehydrin-like protein is regulated by phosphorylation. Plant Physiol. 2002 Oct;130(2):675-87.Moghadam MH, Imenshahidi M, Mohajeri SA. Antihypertensive effect of celery seed on rat blood pressure in chronic administration. J Med Food. 2013 Jun;16(6):558-63.

[2] Peng Y, Zeng X, Feng Y, Wang X. Antiplatelet and antithrombotic activity of L-3-n-butylphthalide in rats. J Cardiovasc Pharmacol. 2004 Jun;43(6):876-81.

[3] Ko FN, Huang TF, Teng CM. Vasodilatory action mechanisms of apigenin isolated from Apium graveolens in rat thoracic aorta. Biochim Biophys Acta.  1991 Nov 14;1115(1):69-74.

[4] Powanda MC, Rainsford KD. A toxicological investigation of a celery seed extract having anti-inflammatory activity. Inflammopharmacology. 2011 Aug;19(4):227-33.

[5] Zhou, Y., et al.  A novel compound from celery seed with a bactericidal effect against Helicobacter pylori.  J Pharm Pharmacol.  61(8):1067-1077, 2009.

[6] Sultana, S., et al.  Inhibitory effect of celery seeds extract on chemically induced hepatocarcinogenesis: modulation of cell proliferation, metabolism and altered hepatic foci development.  Cancer Letters.  221(1):11-20, 2005.

[7] Zheng, G. Q., et al.  Chemoprevention of benzo[a]pyrene-induced forestomach cancer in mice by natural phthalides from celery seed oil.  Nutrition & Cancer.  19(1):77-86, 1993.

[8]Soundararajan, S., et al.  Pilot biomedical study for pain relief in rheumatic pain.  School of Medicine, The University of Queensland, Brisbane, Queensland, Australia, 1991-92.

Venkat, S., et al.  Use of Ayurvedic medicine in the treatment of rheumatic illness. Department of Orthopaedics, Kovai Medical Center and Hospitals, Coimbatore, India, 1995.

[9] Soundararajan, S., et al.  Pilot biomedical study for pain relief in rheumatic pain.  School of Medicine, The University of Queensland, Brisbane, Queensland, Australia, 1991-92.

Venkat, S., et al.  Use of Ayurvedic medicine in the treatment of rheumatic illness. Department of Orthopaedics, Kovai Medical Center and Hospitals, Coimbatore, India, 1995.

[10] Zhang L, Yu WH, Wang YX, et al. DL-3-n-Butylphthalide, an anti-oxidant agent, prevents neurological deficits and cerebral injury following stroke per functional analysis, magnetic resonance imaging and histological assessment. Curr Neurovasc Res. 2012 Aug;9(3):167-75.

[11]Ninety-day administration of dl-3-n-butylphthalide for acute ischemic stroke: a randomized, double-blind trial.

[12] Peng Y, Sun J, Hon S, et al. L-3-n-butylphthalide improves cognitive impairment and reduces amyloid-beta in a transgenic model of Alzheimer’s disease. J Neurosci. 2010 Jun 16;30(24):8180-9.

Chong Z, Feng Y. Protective effects of dl-3-n-butylphthalide on changes of regional cerebral blood flow and blood-brain barrier damage following experimental subarachnoid hemorrhage. Chin Med J (Engl). 1998 Sep;111(9):858-60.

[13] Peng Y, Xu S, Chen G, Wang L, Feng Y, Wang X. l-3-n-Butylphthalide improves cognitive impairment induced by chronic cerebral hypoperfusion in rats. J Pharmacol Exp Ther. 2007 Jun;321(3):902-10.

[14] Peng Y, Hu Y, Xu S, et al. L-3-n-butylphthalide reduces tau phosphorylation and improves cognitive deficits in AbetaPP/PS1-Alzheimer’s transgenic mice. J Alzheimers Dis. 2012;29(2):379-91.

[15] Feng, X; Peng, Y; Liu, M; Cui, L (2011). “Dl-3-n-butylphthalide extends survival by attenuating glial activation in a mouse model of amyotrophic lateral sclerosis”. Neuropharmacology 62 (2): 1004–10. doi:10.1016/j.neuropharm.2011.10.009. PMID 22056419. 

[16] Zhang, T; Yan, W; Li, Q; Fu, J; Liu, K; Jia, W; Sun, X; Liu, X (2011). “3-n-butylphthalide (NBP) attenuated neuronal autophagy and amyloid-beta expression in diabetic mice subjected to brain ischemia”. Neurological research 33 (4): 396–404. doi:10.1179/1743132810Y.0000000006.

[17]Xiong, N; Huang, J; Chen, C; Zhao, Y; Zhang, Z; Jia, M; Zhang, Z; Hou, L; Yang, H; Cao, Xuebing; Liang, Zhihou; Zhang, Yongxue; Sun, Shenggang; Lin, Zhicheng; Wang, Tao (2011). “Dl-3-n-butylphthalide, a natural antioxidant, protects dopamine neurons in rotenone models for Parkinson’s disease”. Neurobiology of Aging 33 (8): 1777. doi:10.1016/j.neurobiolaging.2011.03.007. PMID 21524431.


Resources:

Natural Factors – Celery Seed Standardized Extract (85% 3nB)

Spice Jungle – Celery Seeds (Bulk)


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