Benfotiamine can be used to block Advanced Glycation End Products (AGE’s)

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Benfotiamine is the fat-soluble synthetic S-acyl derivative and precursor compound of thiamine, vitamin B1. When the body absorbs benfotiamine, the substance gets converted from its inactive form into its active form via the body’s metabolic processes.

Consumption of benfotiamine can be used to block Advanced Glycation End (AGE) Products, end products of glycation that have negative detrimental effects on the health of individuals with high blood sugar (especially diabetics). Thus, benfotiamine can be used to reduce such complications as the scarring of blood vessels that function to filter urine from the blood in one’s kidneys, scarring/thickening of lung tissues that lead to interstitial lung disease, and factors associated with aging and age-related chronic diseases. For more details, see Advanced Glycation End Products.

In addition to blocking AGEs, benfotiamine can lessen the severity, delay the progression of, and sometimes even repair damages inflicted by diabetic complications. A case in point would be retinopathy where small blood vessels in the retina are damaged and can gradually lead to blindness. Studies have found that benfotiamine can help prevent this condition.

Benfotiamine has also been found to delay and reduce nephropathy, a disease of the kidney that causes deterioration in the kidney’s ability to function. Oftentimes, individual with nephropathy will have to become dependent on dialysis. Benfotiamine can help normalize the individual’s glucose levels and interfere with the formation of AGEs.

In addition, Benfotiamine can also be used to treat neuropathy, a nerve disorder that damages an individual’s nerves and leaves them feeling a burning, tingling or numbness in their body. Studies have found that large doses of benfotiamine can help improve the condition of patients with neuropathy.


References:

Effectiveness of different benfotiamine dosage regimens in the treatment of painful diabetic neuropathy

Benfotiamine Prevents Macro- and Microvascular Endothelial Dysfunction and Oxidative Stress Following a Meal Rich in Advanced Glycation End Products in Individuals With Type 2 Diabetes

Pharmacokinetics of thiamine derivatives especially of benfotiamine

Effects of low- and high-advanced glycation endproduct meals on macro- and microvascular endothelial function and oxidative stress in patients with type 2 diabetes mellitus1,2,3

Prevention of Incipient Diabetic Nephropathy by High-Dose Thiamine and Benfotiamine

Benfotiamine is similar to thiamine in correcting endothelial cell defects induced by high glucose

High-dose benfotiamine rescues cardiomyocyte contractile dysfunction in streptozotocin-induced diabetes mellitus

Benfotiamine relieves inflammatory and neuropathic pain in rats

The multifaceted therapeutic potential of benfotiamine


PDF Reference Files:

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Benfotiamine – Fights the “Caramelization of the Flesh”

Benfotiamine Inhibits Intracellular Formation of Advanced Glycation End Products in vivo


Informational References:

Benfotiamine.org

Benfotiamine at Clinical Trials.gov


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