Ammonia detoxification


Ammonia is manufactured as a by-product of “depleted” amino acids and endogenous proteins. The leftover nitrogen atoms from depleted amino acids combine with hydrogen to form Ammonia.

Ammonia is combined with endogenous carbon dioxide and excreted from the body via the urine as urea.

Ammonium ions are a toxic waste product of the metabolism in animals. The manufacture of ammonia is a natural byproduct of human metabolism.

When excessive amounts of ammonia are manufactured endogenously in the body and when these excessive amounts are not cleared from the body via the urea cycle there may be toxic effects to the body, such as:

  • damage to the digestive system
  • effect to metabolism such as fatigue
  • toxicity to the nervous system

The following natural substances have been researched and studied for their ability to detoxify excessive ammonia from the body:


Michel, H., et al. Action de l’alpha-cetoglutarate d’ornithine sur l;hyperammoniemie du cirrhotique. La Presse Medicale. 19:867-868, 1971.

Wernerman, J., et al. Alpha-ketoglutarate and postoperative catabolism. Lancet. 335(8691):701-703, 1990.


Schaefer, A., et al. L-arginine reduces exercise-induced increase in plasma lactate and ammonia. Int J Sports Med. 23(6):403-407, 2002.


Llansola, M., et al. Prevention of ammonia and glutamate neurotoxicity by carnitine: molecular mechanisms. Metab Brain Dis. 17(4):389-397, 2002.


Callis, A., et al. Activity of citrulline malate on acid-base balance and blood ammonia and amino acid levels. Study in the animal and in man. Arzneimittelforschung. 41(6):660-663, 1991.


Nakamura, E., et al. Role of glutamine and arginase in protection against ammonia-induced cell death in gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol. 283(6):G1264-G1275, 2002.

Ornithine alpha ketoglutarate

Molinard, R., et al. Modifications de l’aminoacidemie des cirrhotiques sous l’influence de sels ornithine. Ann Nutr Metab. 26:25-36, 1982.


Hilgier, W., et al. Taurine prevents ammonia-induced accumulation of cyclic GMP in rat striatum by interaction with GABAA and glycine receptors. Brain Research. 1043(1-2):242-246, 2005.

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