Allium sativum (Garlic) has antiatherosclerotic effect


Allium sativum, commonly known as garlic, has been shown to have a wide variety of cardiovascular benefits. 

One such benefit includes its antiatherosclerotic effect against plaque buildup in the carotid arteries.  A study published in the journal Atherosclerosis in May 1999 substantiated that not only a preventive but possibly also a curative role in arteriosclerosis therapy (plaque regression) may be ascribed to garlic remedies.

In a randomized, double-blind, placebo-controlled clinical trial, the plaque volumes in both carotid and femoral arteries of 152 probationers were determined. 

“Continuous intake of high-dose garlic powder dragees reduced significantly the increase in arteriosclerotic plaque volume by 5-18% or even effected a slight regression within the observational period of 48 months. Also the age-dependent representation of the plaque volume shows an increase between 50 and 80 years that is diminished under garlic treatment by 6-13% related to 4 years.”  1

Other studies over the years have also demonstrated the antiatherosclerotic effect of allium sativum:

Banerjee, S. K., et al.  Effect of garlic on cardiovascular disorders: a  review.  Nutr J.  1(1):4, 2002.

Breithaupt-Grogler, K., et al.  Protective effect of chronic garlic intake on elastic properties of aorta in the elderly.  Circulation.  96(8):2649-2655, 1997.

Durak, I., et al.  Effects of garlic extract on oxidant/antioxidant status and atherosclerotic plaque formation in rabbit aorta.  Nutr Metab Cardiovasc Dis.  12(3):141-147, 2002.

Durak, I., et al.  Effects of garlic extract consumption on plasma and erythrocyte antioxidant parameters in atherosclerotic patients.  Life Sciences.  75(16):1959-1966, 2004.

Gonen, A., et al.  The antiatherogenic effect of allicin: possible mode of action.  Pathobiology.  72(6):325-334, 2005.

Lau, B. H. S., et al.  Allium sativum (garlic) and atherosclerosis:  A review.  Nutrition Research.  3:119-128, 1983.

Orekhov, A. N., et al.  Direct anti-atherosclerosis-related effects of garlic.  Ann Med.  27(1):63-65, 1995.

Rassoul, F., et al.  The influence of garlic (Allium sativum) extract on interleukin 1alpha-induced expression of endothelial intercellular adhesion molecule-1 and vascular cell adhesion molecule-1.  Phytomedicine.  13(4):230-235, 2006.


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