ADMA: the nitric oxide regulator


Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human cells. It is closely related to L-arginine, a conditionally-essential amino acid.

ADMA interferes with L-arginine in the production of nitric oxide, a key chemical involved in normal endothelial function and, by extension, cardiovascular health.

ADMA (asymmetric dimethylarginine) regulates rates of nitric oxide formation.

Elevated ADMA is a risk factor for:

  • Hypertension
  • Cardiovascular disease
  • Renal failure
  • Erectile dysfunction
  • Insulin resistance and metabolic syndrome
  • Diabetes

Factors contributing to ADMA levels:

  • Increased oxidative challenge
  • Folate acid insufficiency
  • Lifestyle habits
  • Dietary glycemic index
  • Body mass index
  • Dietary sucrose intake
  • Smoking
  • Hormone levels
  • Protein intake

Informational References:

All About ADMA

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