Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. It is a metabolic by-product of continual protein modification processes in the cytoplasm of all human cells. It is closely related to L-arginine, a conditionally-essential amino acid.
ADMA interferes with L-arginine in the production of nitric oxide, a key chemical involved in normal endothelial function and, by extension, cardiovascular health.
ADMA (asymmetric dimethylarginine) regulates rates of nitric oxide formation.
Elevated ADMA is a risk factor for:
- Cardiovascular disease
- Renal failure
- Erectile dysfunction
- Insulin resistance and metabolic syndrome
Factors contributing to ADMA levels:
- Increased oxidative challenge
- Folate acid insufficiency
- Lifestyle habits
- Dietary glycemic index
- Body mass index
- Dietary sucrose intake
- Hormone levels
- Protein intake
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