Activating Adenosine monophosphate-activated protein kinase (AMPK)

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Adenosine monophosphate-activated protein kinase (AMPK) is found in every cell in our body. It serves as the body’s “master regulating switch” that fends off degenerative factors by revitalizing aging cells.

AMPK is involved in reducing fat storage, regulating glucose uptake, creating new mitochondria, and eliminating cellular garbage that accumulates inside aging cells.

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An important property of AMPK is that it induces multiple longevity factors, which have been shown to increase stress-resistance and extend life span in many organisms.

With reduced AMPK signaling, a range of damaging conditions begins to take over a previously healthy body, often leading to an early death. These damaging conditions include:

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Table: Nutraceuticals/Foods/Herbs that Activate AMPK

Activating AMPK

   

Catagory

Nutraceuticals/Foods/Herbs

Reference

Alkaloids

   
 

Berberine

[1]

Amino Acids

   
 

Acetyl-L-Carnitine (ALCAR)

[2]

 

Creatine

[3]

Carbohydrates

   
 

Fucoidan

[4]

Foods

   
 

Bitter Melon

[5]

Herbs

   
 

Gynostemma pentaphyllum

Jiaogulan [6]

 

Rose Hips

Trans- tiliroside [7]

 

Rooibos

[8]

Lipids

   
 

Queen Bee Acid (Royal Jelly)

[9]

 

EPA

[10]

 

DHA

[11]

Polyphenols

   
 

Quercetin

[12]

 

Resveratrol

[13]

 

Curcumin

[14]

 

Apigenin

[15]

 

Hydroxytyrosol

[16]

Quinones

   
 

Coenzyme Q10

[17]

Vitamins

   
 

Alpha Lipoic Acid

[18]

 

Vitamin E

[19]

References:


[6] http://www.ncbi.nlm.nih.gov/pubmed/22576281

Gauhar R, Hwang SL, Jeong SS, et al. Heat-processed Gynostemma pentaphyllum extract improves obesity in ob/ob mice by activating AMP-activated protein kinase. Biotechnol Lett. 2012 Sep;34(9):1607-16.

Nguyen PH, Gauhar R, Hwang SL, et al. New dammarane-type glucosides as potential activators of AMP-activated protein kinase (AMPK) from Gynostemma pentaphyllum. Bioorg Med Chem. 2011 Nov 1;19(21):6254-60.

Lobo SN, Qi YQ, Liu QZ. The effect of Gynostemma pentaphyllum extract on mouse dermal fibroblasts. ISRN Dermatol. 2014 Mar 4.

Muller C, Gardemann A, Keilhoff G, Peter D, Wiswedel I, Schild L. Prevention of free fatty acid-induced lipid accumulation, oxidative stress, and cell death in primary hepatocyte cultures by a Gynostemma pentaphyllum extract. Phytomedicine. 2012 Mar 15;19(5):395-401.

http://www.lef.org/Magazine/2014/SS/AMPK/Page-01

[7] Nagatomo A, Nishida N, Matsuura Y, Shibata N. Rosehip Extract Inhibits Lipid Accumulation in White Adipose Tissue by Suppressing the Expression of Peroxisome Proliferator-activated Receptor Gamma. Prev Nutr Food Sci. 2013 Jun;18(2):85-91

Goto T, Teraminami A, Lee JY, et al. Tiliroside, a glycosidic flavonoid, ameliorates obesity-induced metabolic disorders via activation of adiponectin signaling followed by enhancement of fatty acid oxidation in liver and skeletal muscle in obese-diabetic mice. J Nutr Biochem. 2012 Jul;23(7):768-76.

Shi L, Qin N, Hu L, Liu L, Duan H, Niu W. Tiliroside-derivatives enhance GLUT4 translocation via AMPK in muscle cells. Diabetes Res Clin Pract. 2011 May;92(2):e41-6.

http://www.lef.org/Magazine/2014/SS/AMPK/Page-01