7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone found in:
- Godmania aesculifolia
- Tridax procumbens
- Primula tree leaves
Flavones are a class of flavonoids which are a class of plant secondary metabolites.
Natural flavones include:
- Apigenin (4′,5,7-trihydroxyflavone)
- Luteolin (3′,4′,5,7-tetrahydroxyflavone)
- Tangeritin (4′,5,6,7,8-pentamethoxyflavone)
- Chrysin (5,7-hydroxyflavone)
- Baicalein (5,6,7-trihydroxyflavone)
- Scutellarein (5,6,7,4′-tetrahydroxyflavone)
- Wogonin (5,7-dihydroxy-8-methoxyflavone)
Synthetic flavones include:
- 7,8-dihydroxyflavone (7,8-DHF)
7,8-Dihydroxyflavone (7,8-DHF) has been determined and studied to be a potent and selective agonist of the TrkB receptor, which is the main signaling receptor of brain-derived neurotrophic factor (BDNF). It is able to penetrate the blood-brain-barrier after oral consumption.
7,8-DHF has been very therapeutically efficient in various central nervous system disorders including:
- Depression 
- Alzheimer’s disease 
- Schizophrenia 
- Parkinson’s disease 
- Huntington’s disease 
- Amyotrophic lateral sclerosis 
- Traumatic brain injury 
- Cerebral ischemia 
7,8-DHF has also been found to be a potent antioxidant  and provides neuroprotection against glutamate-induced excitotoxicity.
The authors of the study concluded that:
Our data demonstrate that 7,8-DHF protects against hydrogen peroxide and menadione-induced cell death, suggesting that 7,8-DHF has an antioxidant effect. In summary, although 7,8-DHF is considered as a selective TrkB agonist, our results demonstrate that 7,8-DHF can still confer neuroprotection against glutamate-induced toxicity in HT-22 cells via its antioxidant activity.” 
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